Drug Information

Drug General Information
Drug ID
D03HJZ
Former ID
DIB010858
Drug Name
AZ-11657312
Synonyms
AZ-11657312; P2X7 purinoceptor antagonists (inflammation); P2X7 purinoceptor antagonists (inflammation), AstraZeneca
Indication Inflammatory disease [ICD9: 140-229, 147, 173, 573.3, 710-719; ICD10:C11, C44, K75.9, M00-M25] Investigative [543850]
Company
AstraZeneca plc
Canonical SMILES
C12(CC(=O)Nc3cc4[nH]ncc4cc3)CC3CC(C2)CC(C1)C3
Target and Pathway
Target(s) P2X purinoceptor 7 Target Info Antagonist [543850]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Reactome The NLRP3 inflammasome
WikiPathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
References
Ref 543850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484).
Ref 543850(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 484).

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