Drug Information

Drug General Information
Drug ID
D03DEJ
Former ID
DIB018992
Drug Name
BMS614
Synonyms
BMS 614; BMS-614
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539709]
Formula
C29H24N2O3
InChI
InChI=1S/C29H24N2O3/c1-29(2)14-13-23(21-15-19-5-3-4-6-26(19)30-17-21)24-16-20(9-12-25(24)29)27(32)31-22-10-7-18(8-11-22)28(33)34/h3-13,15-17H,14H2,1-2H3,(H,31,32)(H,33,34)
InChIKey
WGLMBRZXZDAQHP-UHFFFAOYSA-N
PubChem Compound ID
445091
PubChem Substance ID
837265, 10299631, 36887910, 50948432, 104633543, 118043378, 129578080, 135650004, 140274230, 174496040, 208265529, 232446631, 241376567, 249617942, 249815169, 252157434
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Antagonist [526251]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539709(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2643).
Ref 526251Co-regulator recruitment and the mechanism of retinoic acid receptor synergy. Nature. 2002 Jan 10;415(6868):187-92.

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