Drug Information

Drug General Information
Drug ID
D03CFJ
Former ID
DIB002709
Drug Name
NCX-701
Synonyms
Nitroparacetamol; NO-acetaminophen, NicOx; NO-paracetamol, NicOx
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Discontinued in Phase 2 [547214]
Company
NicOx SA
Formula
C12H14N2O6
Canonical SMILES
[N+](=O)([O-])OCCCC(=O)Oc1ccc(NC(=O)C)cc1
CAS Number
CAS 326850-30-0
PubChem Compound ID
6918532
Target and Pathway
Target(s) Cyclooxygenase Target Info Modulator [529064], [544102]
References
Ref 547214Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014096)
Ref 529064Nitroparacetamol (NCX-701) and pain: first in a series of novel analgesics. CNS Drug Rev. 2007 Fall;13(3):279-95.
Ref 544102Antinociceptive effects of NCX-701 (nitro-paracetamol) in neuropathic rats: enhancement of antinociception by co-administration with gabapentin. Br J Pharmacol. 2009 September; 158(2): 601-609.

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