Drug Information

Drug General Information
Drug ID
D02RWC
Former ID
DIB019925
Drug Name
GNF-5837
Synonyms
GNF 5837; GNF5837
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532813]
Formula
C28H21F4N5O2
InChI
InChI=1S/C28H21F4N5O2/c1-15-4-6-19(35-27(39)37-25-11-16(28(30,31)32)5-9-22(25)29)13-23(15)34-18-7-8-20-21(12-17-3-2-10-33-17)26(38)36-24(20)14-18/h2-14,33-34H,1H3,(H,36,38)(H2,35,37,39)/b21-12-
InChIKey
YYDUWLSETXNJJT-MTJSOVHGSA-N
PubChem Compound ID
59397065
PubChem Substance ID
140926237, 160673720, 160863810, 172088884, 210274863, 210280497, 223366895, 223382067, 229612162, 241377057, 249565751, 249691227, 251910202, 251962680, 252158171, 252160857, 252215480, 252450786, 252471818, 252543455
Target and Pathway
Target(s) BDNF/NT-3 growth factors receptor Target Info Inhibitor [532813]
Trk receptor Target Info Inhibitor [532813]
KEGG Pathway MAPK signaling pathway
Neurotrophin signaling pathway
Alcoholism
Pathway Interaction Database SHP2 signaling
Posttranslational regulation of adherens junction stability and dissassembly
Neurotrophic factor-mediated Trk receptor signaling
Reactome NGF-independant TRKA activationR-HSA-170984:ARMS-mediated activation
NGF-independant TRKA activation
PI3K/AKT activation
WikiPathways SIDS Susceptibility Pathways
BDNF signaling pathwayWP382:MAPK Signaling Pathway
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
NGF signalling via TRKA from the plasma membrane
References
Ref 532813Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5.
Ref 532813Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models. ACS Med Chem Lett. 2012 Jan 1;3(2):140-5.

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