Drug Information

Drug General Information
Drug ID
D02REM
Former ID
DIB003361
Drug Name
DPI-221
Indication Urinary incontinence [ICD9: 788.3; ICD10:N39.3, N39.4, R32] Investigative [543762]
Company
Ardent Pharmaceuticals Inc
Canonical SMILES
[C@@H](N1[C@H](CN([C@@H](C1)C)Cc1cc(ccc1)F)C)(c1ccc(cc1<br />)C(=O)N(CC)CC)c1ccccc1
Target and Pathway
Target(s) Delta-type opioid receptor Target Info Agonist [543762]
KEGG Pathway cGMP-PKG signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Opioid proenkephalin pathway
Opioid proopiomelanocortin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 543762(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).
Ref 543762(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 317).

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