Drug Information

Drug General Information
Drug ID
D02QTU
Former ID
DIB015025
Drug Name
CRTh2 receptor antagonists
Synonyms
CRTh2 receptor antagonists (inflammatory/allergic diseases); CRTh2 receptor antagonists (inflammatory/allergic diseases), Novartis; DP2 receptor antagonists (inflammatory/allergic diseases), Novartis
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Investigative [532474]
Company
Novartis AG
Canonical SMILES
C(=O)(Cc1c2c(nccc2)n(c1C)S(=O)(=O)c1cc(c(cc1)F)F)O
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Antagonist [543776]
Reactome Prostanoid ligand receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 532474Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.
Ref 543776(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 339).

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