Drug Information

Drug General Information
Drug ID
D02PIN
Former ID
DIB015880
Drug Name
GR-94839
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Terminated [545572]
Company
Glaxo Group Research Ltd
Formula
C19H25Cl2N3O3
Canonical SMILES
N1(C(CN(C(=O)C)CC1)CN1CC(CC1)O)C(=O)Cc1cc(c(cc1)Cl)Cl
CAS Number
CAS 133407-20-2
PubChem Compound ID
131626
Target and Pathway
Target(s) Kappa-type opioid receptor Target Info Modulator [526749]
KEGG Pathway Neuroactive ligand-receptor interaction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Opioid prodynorphin pathway
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 545572Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003733)
Ref 526749GR94839, a kappa-opioid agonist with limited access to the central nervous system, has antinociceptive activity. Br J Pharmacol. 1992 Aug;106(4):783-9.

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