Drug Information

Drug General Information
Drug ID
D02LFU
Former ID
DNC005724
Drug Name
1-Benzenesulfonyl-3-piperidin-3-yl-1H-indole
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527703]
Formula
C19H20N2O2S
Canonical SMILES
C1CC(CNC1)C2=CN(C3=CC=CC=C32)S(=O)(=O)C4=CC=CC=C4
InChI
1S/C19H20N2O2S/c22-24(23,16-8-2-1-3-9-16)21-14-18(15-7-6-12-20-13-15)17-10-4-5-11-19(17)21/h1-5,8-11,14-15,20H,6-7,12-13H2
InChIKey
QUUSSZWUXRDTJG-UHFFFAOYSA-N
PubChem Compound ID
9902533
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527703]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 527703Bioorg Med Chem Lett. 2005 Nov 1;15(21):4780-5.Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.
Ref 527703Bioorg Med Chem Lett. 2005 Nov 1;15(21):4780-5.Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists.

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