Drug Information

Drug General Information
Drug ID
D02KLD
Former ID
DIB006976
Drug Name
BVT-74316
Synonyms
BVT-5182; BVT-5182C; 5-HT6 antagonists (obesity), Biovitrum; 5-HT6 antagonists (obesity), Proximagen
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 1 [548202]
Company
Swedish Orphan Biovitrum AB
Formula
C21H24N2O5S
Canonical SMILES
c1(ccc(c(c1)NS(=O)(=O)c1cc2c(c(c1)OC1CCNCC1)occ2)OC)C
PubChem Compound ID
16092139
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [544074]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548202Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023034)
Ref 544074Pharmacological targeting of the serotonergic system for the treatment of obesity. J Physiol. 2009 January 1; 587(Pt 1): 49-60.

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