Drug Information

Drug General Information
Drug ID
D02JUW
Former ID
DNC009129
Drug Name
GUAIACOL
Drug Type
Small molecular drug
Indication Discovery agent Phase 3 [523035]
Formula
C7H8O2
Canonical SMILES
COC1=CC=CC=C1O
InChI
1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3
InChIKey
LHGVFZTZFXWLCP-UHFFFAOYSA-N
PubChem Compound ID
460
Target and Pathway
Target(s) Carbonic anhydrase II Target Info Inhibitor [529973]
KEGG Pathway Nitrogen metabolism
Proximal tubule bicarbonate reclamation
Collecting duct acid secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
NetPath Pathway IL4 Signaling Pathway
EGFR1 Signaling Pathway
Reactome Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide
WikiPathways Reversible Hydration of Carbon Dioxide
Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 523035ClinicalTrials.gov (NCT01119534) Comparative Efficacy of the Suppository Versus Guaiacol Suppository Versus Guaifenesin Syrup in Pediatric Patients With Cough Due the Infectious Origin. U.S. NationalInstitutes of Health.
Ref 529973Bioorg Med Chem. 2009 Apr 15;17(8):3207-11. Epub 2009 Feb 4.Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.

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