Drug Information

Drug General Information
Drug ID
D02JFD
Former ID
DIB020915
Drug Name
SB399885
Synonyms
SB-399885; SB-399,885; SB 399885
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540214]
Formula
C18H21Cl2N3O4S
InChI
InChI=1S/C18H21Cl2N3O4S/c1-26-17-4-3-13(11-16(17)23-7-5-21-6-8-23)28(24,25)22-15-10-12(19)9-14(20)18(15)27-2/h3-4,9-11,21-22H,5-8H2,1-2H3
InChIKey
ATKZKAYWARYLBW-UHFFFAOYSA-N
PubChem Compound ID
6918649
PubChem Substance ID
12015655, 14906235, 17195020, 43530014, 52242311, 57371996, 104238855, 114788301, 134223376, 137010139, 141679218, 143028941, 163368076, 178100292, 223852766, 231287615, 241376299, 245164363, 249617776, 252157078
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [528500]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 540214(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3241).
Ref 528500SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models. Eur J Pharmacol. 2006 Dec 28;553(1-3):109-19. Epub 2006 Sep 29.

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