Drug Information

Drug General Information
Drug ID
D02HWR
Former ID
DIB014778
Drug Name
PV-1019
Synonyms
Checkpoint kinase 2 inhibitor (cancer), Provid Pharmaceuticals; Chk2 inhibitor (cancer), Provid Pharmaceuticals
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [525367]
Company
Provid Pharmaceuticals Inc
Canonical SMILES
c1ccc2c(c1[N+](=O)[O-])[nH]c(c2)C(=O)Nc1ccc(cc1)/C(=N/N<br />C(=N)N)/C
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk2 Target Info Inhibitor [525367]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling events
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 525367Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331(3):816-26.
Ref 525367Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. J Pharmacol Exp Ther. 2009 Dec;331(3):816-26.

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