TTD | Drug: D02CFR

Drug General Information
Drug ID	D02CFR
Former ID	DIB006237
Drug Name	GW-559768X
Synonyms	GW-559768X; GW-569998X; GW-578257A; GW-585550A; RET tyrosine kinase inhibitors (cancer); RET tyrosine kinase inhibitors (cancer), GlaxoSmithKline
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543572]
Company	GlaxoSmithKline plc
Canonical SMILES	O=S(=O)(c1ccc2c(c1)c(ccn2)Nc1c(cc(c(c1)O)F)O)C
Target and Pathway
Target(s)	Proto-oncogene tyrosine-protein kinase receptor ret	Target Info	Inhibitor	[543572]
KEGG Pathway	Endocytosis
	Pathways in cancer
	Thyroid cancer
	Central carbon metabolism in cancer
Pathway Interaction Database	Signaling events regulated by Ret tyrosine kinase
Pathway Interaction Database	Posttranslational regulation of adherens junction stability and dissassembly
WikiPathways	SIDS Susceptibility Pathways
WikiPathways	Dopaminergic Neurogenesis
References
Ref 543572	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).
Ref 543572	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2185).

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Drug Information