Drug Information

Drug General Information
Drug ID
D02BXC
Former ID
DNC014634
Drug Name
GNF-PF-117
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534009]
Formula
C16H13NO2
Canonical SMILES
COC1=CC2=C(C=C1)NC(=CC2=O)C3=CC=CC=C3
InChI
1S/C16H13NO2/c1-19-12-7-8-14-13(9-12)16(18)10-15(17-14)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
InChIKey
CKFBIYVXNYYXAI-UHFFFAOYSA-N
PubChem Compound ID
124348
Target and Pathway
Target(s) Tubulin beta Target Info Inhibitor [534009]
Tubulin Target Info Inhibitor [534009]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 534009J Med Chem. 1993 Apr 30;36(9):1146-56.Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.
Ref 534009J Med Chem. 1993 Apr 30;36(9):1146-56.Synthesis and cytotoxicity of 1,6,7,8-substituted 2-(4'-substituted phenyl)-4-quinolones and related compounds: identification as antimitotic agents interacting with tubulin.

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