Drug Information

Drug General Information
Drug ID
D02BRJ
Former ID
DIB010659
Drug Name
Vabicaserin
Synonyms
Vabicaserin hydrochloride; PF-05208769; PF-5208769; SCA-136; WY-16629
Drug Type
Small molecular drug
Indication Psychotic disorders [ICD9: 290-299; ICD10:F20-F29] Phase 2 [522459]
Company
Wyeth
Formula
C15H20N2
Canonical SMILES
N12c3c(CNCC1)cccc3[C@@H]1[C@H](C2)CCC1
PubChem Compound ID
11521822
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Modulator [531390]
5-hydroxytryptamine 2C receptor Target Info Modulator [531390]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signaling
References
Ref 522459ClinicalTrials.gov (NCT00768612) Study Evaluating Safety and Tolerability of Vabicaserin in Patients With Sudden Worsening of Schizophrenia. U.S. National Institutes of Health.
Ref 531390Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist. J Pharmacol Exp Ther. 2011 Jun;337(3):673-80.

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