Drug Information

Drug General Information
Drug ID
D01XEO
Former ID
DIB007323
Drug Name
Debio-0824
Synonyms
Debio-0824; ShK-186; Shk-192; ShK analogs (Subcutaneous formulation, autoimmune disease), Kineta; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitors (injectable peptide, autoimmune disease); Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitor (Subcutaneous formulation, autoimmune disease), Airmid; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitor (injectable peptide, autoimmune disease), Davis; Stichodactyla helianthus-derived Kv1.3 potassium channel inhibitors (injectable peptide, autoimmune disease), Kineta One
Indication Psoriatic arthritis [ICD9: 696; ICD10:L40.5, M07] Phase 1 [525193]
Company
Kineta
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily A member 3 Target Info Inhibitor [544248]
Reactome Voltage gated Potassium channels
WikiPathways Potassium Channels
BDNF signaling pathway
References
Ref 525193ClinicalTrials.gov (NCT02446340) Multiple Ascending Dose Safety Study of ShK-186 (Dalazatide) in Healthy Volunteers. U.S. National Institutes of Health.
Ref 544248Durable Pharmacological Responses from the Peptide ShK-186, a Specific Kv1.3 Channel Inhibitor That Suppresses T Cell Mediators of Autoimmune Disease. J Pharmacol Exp Ther. 2012 September; 342(3): 642-653.

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