Drug Information

Drug General Information
Drug ID
D01WVE
Former ID
DIB020126
Drug Name
KB-130015
Synonyms
KB 130015; KB130015
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542637]
Formula
C18H14I2O4
InChI
InChI=1S/C18H14I2O4/c1-10-13(12-4-2-3-5-16(12)24-10)6-11-7-14(19)18(15(20)8-11)23-9-17(21)22/h2-5,7-8H,6,9H2,1H3,(H,21,22)
InChIKey
OLIKCJUMYWSDIV-UHFFFAOYSA-N
PubChem Compound ID
9872203
PubChem Substance ID
14837197, 24162577, 45294460, 49861758, 80751623, 87692422, 103407415, 104003972, 125691933, 128825620, 137038561, 162274499, 162453428, 198981193, 223365994, 223369722, 225008818, 229249338, 241036802, 249581877
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Activator [530653]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 542637(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7659).
Ref 530653The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism. Eur J Pharmacol. 2010 Apr 25;632(1-3):52-9.

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