Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D01TDV
|
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| Former ID |
DIB019176
|
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| Drug Name |
compound 1
|
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| Drug Type |
Small molecular drug
|
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| Formula |
C25H28N6O2
|
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| InChI |
InChI=1S/C25H28N6O2/c1-29-12-14-30(15-13-29)22-10-5-19(16-23(22)33-3)27-24-11-4-18-17-26-31(25(18)28-24)20-6-8-21(32-2)9-7-20/h4-11,16-17H,12-15H2,1-3H3,(H,27,28)
|
||||
| InChIKey |
LZQFMCFJCXQTTG-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | mRNA of Aurora B | Target Info | Inhibitor | [532161] | |
| STK33 | Target Info | Inhibitor | [531549] | ||
| Protein kinase A | Target Info | Inhibitor | [532161] | ||
| Pathway Interaction Database | Aurora B signaling | ||||
| Signaling by Aurora kinases | |||||
| Aurora C signaling | |||||
| FOXM1 transcription factor network | |||||
| Aurora A signaling | |||||
| References | |||||
| Ref 531549 | STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. | ||||
| Ref 532161 | A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22. | ||||
| Ref 531549 | STK33 kinase activity is nonessential in KRAS-dependent cancer cells. Cancer Res. 2011 Sep 1;71(17):5818-26. | ||||
| Ref 532161 | A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038. Epub 2012 Oct 22. | ||||
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