Drug Information

Drug General Information
Drug ID
D01SGM
Former ID
DIB001933
Drug Name
FK-906
Synonyms
FR-115906
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [545037]
Company
Fujisawa Pharmaceutical Co Ltd
Formula
C40H64ClN7O7
Canonical SMILES
C(=O)(N([C@H](C(=O)N[C@@H](CC1CCCCC1)[C@H](CCC(C)C)O)Cc<br />1nc[nH]c1)C)[C@@H](OC(=O)N(CCN(C(=O)N1CCOCC1)C)C)Cc1ccc<br />cc1.Cl
PubChem Compound ID
6918227
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [533996]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 545037Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001939)
Ref 533996Antihypertensive efficacy of FK906, a novel human renin inhibitor. Clin Ther. 1993 May-Jun;15(3):539-48.

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