Drug Information

Drug General Information
Drug ID
D01RQK
Former ID
DIB018484
Drug Name
15-deoxy-Delta12,14-PGJ2
Synonyms
15d-Delta12,14-PGJ2; 15deoxy-delta-12,14-PGJ2; LS-125843
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539177]
Formula
C20H28O3
InChI
InChI=1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6-,18-13+/t17-/m0/s1
InChIKey
VHRUMKCAEVRUBK-WKELIDJCSA-N
PubChem Compound ID
5283035
PubChem Substance ID
535266, 11038694, 39316452, 50026809, 53801020, 57358811, 80464935, 103648492, 113858901, 139340679, 227651811, 241153206, 252391955, 252464264
Target and Pathway
Target(s) Putative G-protein coupled receptor 44 Target Info Agonist [526611]
Prostaglandin D2 receptor Target Info Agonist [534620]
KEGG Pathway Neuroactive ligand-receptor interaction
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Small Ligand GPCRs
GPCR downstream signaling
References
Ref 539177(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1877).
Ref 526611Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. Epub 2003 Apr 29.
Ref 534620Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist. Br J Pharmacol. 1998 Apr;123(7):1317-24.

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