Drug Information

Drug General Information
Drug ID
D01QSG
Former ID
DNCL001733
Drug Name
VTP-27999
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Phase 1 [523201]
Company
Vitae Pharmaceuticals
Formula
C26H41ClN4O5
Canonical SMILES
CNC(CC1CCCOC1)CNC(=O)N2CCCC(C2)C(C3=CC(=CC=C3)Cl)OCCNC(<br />=O)OC
InChI
1S/C26H41ClN4O5/c1-28-23(14-19-6-5-12-35-18-19)16-30-25(32)31-11-4-8-21(17-31)24(20-7-3-9-22(27)15-20)36-13-10-29-26(33)34-2/h3,7,9,15,19,21,23-24,28H,4-6,8,10-14,16-18H2,1-2H3,(H,29,33)(H,30,32)/t19-,21-,23+,24?/m1/s1
InChIKey
NXWASIVXQMMPLM-SMTXQXLZSA-N
PubChem Compound ID
66577056
PubChem Substance ID
152258828, 160647679, 185990435, 252493683
Target and Pathway
Target(s) Renin, renal Target Info Inhibitor [544476]
KEGG Pathway Renin-angiotensin system
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 523201ClinicalTrials.gov (NCT01217736) Direct Renin Inhibition and the Kidney. U.S. National Institutes of Health.
Ref 544476New Developments in the Pharmacological Treatment of Hypertension: Dead-End or a Glimmer at the Horizon?. Curr Hypertens Rep. 2015; 17(6): 42.

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