Drug Information

Drug General Information
Drug ID
D01ORM
Former ID
DIB001950
Drug Name
Mitonafide
Synonyms
Mitonafide < Rec INN >; N-[2-(Dimethylamino)ethyl]-3-nitronaphthalimide; 2-[2-(Dimethylamino)ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Discontinued in Phase 2 [545276]
Formula
C16H15N3O4
Canonical SMILES
CN(C)CCN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+](=O)[O-]
InChI
1S/C16H15N3O4/c1-17(2)6-7-18-15(20)12-5-3-4-10-8-11(19(22)23)9-13(14(10)12)16(18)21/h3-5,8-9H,6-7H2,1-2H3
InChIKey
XXVLKDRPHSFIIB-UHFFFAOYSA-N
CAS Number
CAS 54824-17-8
PubChem Compound ID
327044
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [534235]
References
Ref 545276Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002671)
Ref 534235Effect of mitonafide analogs on topoisomerase II of Leishmania chagasi. Antimicrob Agents Chemother. 1996 Mar;40(3):706-9.

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