Drug Information

Drug General Information
Drug ID
D01OMG
Former ID
DIB020576
Drug Name
NS9283
Synonyms
NS-9283
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540609]
Formula
C14H8N4O
InChI
InChI=1S/C14H8N4O/c15-8-10-3-1-4-11(7-10)14-17-13(18-19-14)12-5-2-6-16-9-12/h1-7,9H
InChIKey
HGFXDSQLRSWUBO-UHFFFAOYSA-N
PubChem Compound ID
11998180
PubChem Substance ID
17497342, 24500684, 37446558, 79321301, 141669600, 178100819, 188377297, 188377299, 194173553, 194943507, 224189866, 227634345, 242896807, 249691401, 249896026, 252158608
Target and Pathway
Target(s) Neuronal acetylcholine receptor protein, beta-2 chain Target Info Modulator (allosteric modulator) [531561]
KEGG Pathway Neuroactive ligand-receptor interaction
Cholinergic synapse
Nicotine addiction
PANTHER Pathway Nicotinic acetylcholine receptor signaling pathway
Nicotine pharmacodynamics pathway
Reactome Highly sodium permeable acetylcholine nicotinic receptors
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
Highly calcium permeable nicotinic acetylcholine receptors
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nicotine Activity on Dopaminergic Neurons
References
Ref 540609(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3993).
Ref 531561alpha4beta2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of alpha4beta2 nAChR agonists in pain. Biochem Pharmacol. 2011 Oct 15;82(8):959-66.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.