Drug Information

Drug General Information
Drug ID
D01IFO
Former ID
DNC011063
Drug Name
6-(3-(trifluoromethyl)phenyl)picolinonitrile
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530989]
Formula
C13H7F3N2
Canonical SMILES
C1=CC(=CC(=C1)C(F)(F)F)C2=CC=CC(=N2)C#N
InChI
1S/C13H7F3N2/c14-13(15,16)10-4-1-3-9(7-10)12-6-2-5-11(8-17)18-12/h1-7H
InChIKey
FYQRYAIHFASLNM-UHFFFAOYSA-N
PubChem Compound ID
49863205
Target and Pathway
Target(s) Cathepsin S Target Info Inhibitor [530989]
KEGG Pathway Lysosome
Phagosome
Antigen processing and presentation
Tuberculosis
NetPath Pathway Leptin Signaling Pathway
IL2 Signaling Pathway
Reactome Endosomal/Vacuolar pathway
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
WikiPathways Class I MHC mediated antigen processing & presentation
Trafficking and processing of endosomal TLR
References
Ref 530989Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10. Epub 2010 Jun 10.4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.
Ref 530989Bioorg Med Chem Lett. 2010 Aug 1;20(15):4507-10. Epub 2010 Jun 10.4-(3-Trifluoromethylphenyl)-pyrimidine-2-carbonitrile as cathepsin S inhibitors: N3, not N1 is critically important.

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