Drug Information

Drug General Information
Drug ID
D01HJZ
Former ID
DNC010213
Drug Name
N,N-dimethyl-2,2-diphenylethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530331]
Formula
C16H19N
Canonical SMILES
CN(C)CC(C1=CC=CC=C1)C2=CC=CC=C2
InChI
1S/C16H19N/c1-17(2)13-16(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,16H,13H2,1-2H3
InChIKey
UAUJDKBNVRSJBD-UHFFFAOYSA-N
PubChem Compound ID
83632
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [530331]
Histamine H1 receptor Target Info Inhibitor [530331]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390650:Histamine receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP58:Monoamine GPCRs
IL-4 Signaling Pathway
References
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.
Ref 530331Bioorg Med Chem. 2009 Sep 15;17(18):6496-504. Epub 2009 Aug 13.Synthesis, structure-affinity relationships, and modeling of AMDA analogs at 5-HT2A and H1 receptors: structural factors contributing to selectivity.

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