Drug Information

Drug General Information
Drug ID
D01GRB
Former ID
DIB018561
Drug Name
2MeSAMP
Synonyms
2-methylthio-AMP; poly(2'-methylthioadenylic acid)
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539114]
Formula
C11H16N5O7PS
InChI
InChI=1S/C11H16N5O7PS/c1-25-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(23-10)2-22-24(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H2,12,14,15)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
InChIKey
XVTFTCNRRAQHEQ-KQYNXXCUSA-N
PubChem Compound ID
189762
PubChem Substance ID
10261068, 33511191, 57396373, 80328931, 103106354, 103723120, 113446815, 117626873, 135081611, 135651402, 138814621, 162901334, 228630362
Target and Pathway
Target(s) P2Y13 receptor Target Info Antagonist [526649]
P2Y purinoceptor 12 Target Info Antagonist [526120]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539114(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1764).
Ref 526120Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y(1) receptor. Mol Pharmacol. 2001 Sep;60(3):432-9.
Ref 526649Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.

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