Drug Information

Drug General Information
Drug ID
D01GAR
Former ID
DNC013550
Drug Name
1-[(n-hex-1-ylamino)ethyl]-1,1-bisphosphonic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529229]
Formula
C8H21NO6P2
Canonical SMILES
CCCCCCNCC(P(=O)(O)O)P(=O)(O)O
InChI
1S/C8H21NO6P2/c1-2-3-4-5-6-9-7-8(16(10,11)12)17(13,14)15/h8-9H,2-7H2,1H3,(H2,10,11,12)(H2,13,14,15)
InChIKey
QDLXIUDMSHZYCG-UHFFFAOYSA-N
PubChem Compound ID
19689034
Target and Pathway
Target(s) Farnesyl pyrophosphatesynthetase Target Info Inhibitor [529229]
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Influenza A
HTLV-I infection
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
WikiPathways Activation of Gene Expression by SREBP (SREBF)
SREBP signalling
Cholesterol Biosynthesis
References
Ref 529229Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. Epub 2007 Dec 10.Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.
Ref 529229Bioorg Med Chem. 2008 Mar 15;16(6):3283-90. Epub 2007 Dec 10.Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase.

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