Drug Information

Drug General Information
Drug ID
D01EJJ
Former ID
DIB005412
Drug Name
JTE-051
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Phase 1 [549363]
Target and Pathway
Target(s) Tyrosine-protein kinase itk/tsk Target Info Inhibitor [550352]
KEGG Pathway Chemokine signaling pathway
T cell receptor signaling pathway
Leukocyte transendothelial migration
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
TCR signaling in na&#xef
Class I PI3K signaling events
Reactome Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
WikiPathways TCR Signaling Pathway
T-Cell Receptor and Co-stimulatory Signaling
TCR signaling
References
Ref 549363Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035711)
Ref 550352Characterisation of a K390R ITK Kinase Dead Transgenic Mouse - Implications for ITK as a Therapeutic Target. PLoS One. 2014; 9(9): e107490.

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