Drug Information

Drug General Information
Drug ID
D01BKS
Former ID
DIB019906
Drug Name
ginsenoside Rg3
Synonyms
(20S)-ginsenoside Rg3
Drug Type
Small molecular drug
Indication Discovery agent Investigative [542636]
Formula
C42H72O13
InChI
InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1
InChIKey
RWXIFXNRCLMQCD-JBVRGBGGSA-N
PubChem Compound ID
9918693
PubChem Substance ID
14889154, 16043242, 24196830, 45990334, 51284473, 56459455, 81044365, 93575954, 103557519, 104151898, 119526355, 160711129, 162204952, 163913781, 198971721, 210280263, 210282243, 223365993, 252350174
Target and Pathway
Target(s) Potassium voltage-gated channel subfamily H member 2 Target Info Activator [531483]
PathWhiz Pathway Muscle/Heart Contraction
Reactome Voltage gated Potassium channels
WikiPathways SIDS Susceptibility Pathways
Hematopoietic Stem Cell Differentiation
Potassium Channels
References
Ref 542636(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7658).
Ref 531483Ginsenoside Rg(3) decelerates hERG K(+) channel deactivation through Ser631 residue interaction. Eur J Pharmacol. 2011 Aug 1;663(1-3):59-67.

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