Drug Information

Drug General Information
Drug ID
D00ZCU
Former ID
DIB019041
Drug Name
BW723C86
Synonyms
BW-72386
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538986]
Formula
C16H18N2OS
InChI
InChI=1S/C16H18N2OS/c1-11(17)7-12-9-18-16-5-4-13(8-15(12)16)19-10-14-3-2-6-20-14/h2-6,8-9,11,18H,7,10,17H2,1H3
InChIKey
ALFGDCNSEBJYSP-UHFFFAOYSA-N
PubChem Compound ID
4284720
PubChem Substance ID
6290685, 9627880, 14775550, 26752051, 35542782, 47647584, 47647585, 47944872, 50104701, 78349774, 85208991, 85787313, 90340994, 112845779, 123100913, 124749550, 124879375, 124879376, 125334647, 127422847, 135312522, 135650041, 136350443, 137226870, 162220640, 179586539, 229327124
Target and Pathway
Target(s) 5-hydroxytryptamine 2C receptor Target Info Agonist [526719]
5-hydroxytryptamine 2B receptor Target Info Agonist [526719]
5-hydroxytryptamine 2A receptor Target Info Agonist [527178]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, Other
References
Ref 538986(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 161).
Ref 526719Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. Br J Pharmacol. 2003 Sep;140(2):277-84. Epub 2003 Aug 11.
Ref 527178Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30.

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