Drug Information

Drug General Information
Drug ID
D00WBN
Former ID
DIB008021
Drug Name
ALV-003
Synonyms
Gluten-detoxifying protease (celiac sprue), Alvine Pharmaceuticals; Glutamine-specific cysteine protease (EP-B2) + proline-specific prolyl endopeptidase (PEP) (celiac disease), Alvine
Indication Celiac disease [ICD9: 579; ICD10:K90.0] Phase 2 [522758]
Company
Alvine Pharmaceuticals Inc
Target and Pathway
Target(s) Prolyl endopeptidase Target Info Modulator [530542]
KEGG Pathway Renin-angiotensin system
PANTHER Pathway Vasopressin synthesis
References
Ref 522758ClinicalTrials.gov (NCT00959114) Safety and Efficacy of ALV003 for the Treatment of Celiac Disease. U.S. National Institutes of Health.
Ref 530542The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010 Mar;134(3):289-95.

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