Drug Information

Drug General Information
Drug ID
D00VZF
Former ID
DIB007605
Drug Name
Merbarone
Synonyms
NSC-336628
Drug Type
Small molecular drug
Indication Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10:C25] Discontinued in Phase 2 [544761]
Company
Uniroyal Chemical Co Inc
Formula
C11H9N3O3S
Canonical SMILES
C1(=O)NC(=S)NC(=O)C1C(=O)Nc1ccccc1
CAS Number
CAS 97534-21-9
PubChem Compound ID
4990817
Target and Pathway
Target(s) DNA topoisomerase II Target Info Modulator [532018]
References
Ref 544761Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000894)
Ref 532018The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res. 2012 Oct-Nov;738-739:45-51.

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