Drug Information

Drug General Information
Drug ID
D00QXB
Former ID
DIB009629
Drug Name
WT1 peptide vaccine
Synonyms
WT1 peptide vaccine (cancer); WT1 peptide vaccine (cancer), Charity Medical School of the Humboldt University of Berlin; Cancer vaccine (Wilms tumor gene 1 + KLH + GM-CSF advuvants), Humboldt University of Berlin
Drug Type
Vaccine
Indication Leukemia [ICD9: 208.9; ICD10:C90-C95] Phase 2 [523307]
Company
Charity Medical School of the Humboldt University of Berlin
Target and Pathway
Target(s) Wilms' tumor protein Target Info [531614]
KEGG Pathway Transcriptional misregulation in cancer
NetPath Pathway FSH Signaling Pathway
IL5 Signaling Pathway
Pathway Interaction Database p73 transcription factor network
Regulation of Telomerase
WikiPathways Primary Focal Segmental Glomerulosclerosis FSGS
Integrated Pancreatic Cancer Pathway
References
Ref 523307ClinicalTrials.gov (NCT01266083) Trial of a WT-1 Analog Peptide Vaccine in Patients With Acute Myeloid Leukemia (AML) or Acute Lymphoblastic Leukemia (ALL). U.S. National Institutes of Health.
Ref 531614Wilms' tumor protein 1 (WT1) peptide vaccination in AML patients: predominant TCR CDR3beta sequence associated with remission in one patient is detectable in other vaccinated patients. Cancer ImmunolImmunother. 2012 Mar;61(3):313-22.

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