Drug Information

Drug General Information
Drug ID
D00NXT
Former ID
DNCL003798
Drug Name
Xmab 5871
Synonyms
XmAb 5871 (TN)
Indication Autoimmune diabetes [ICD10:E08-E13] Phase 2 [549317]
Company
Amgen; Xencor
Target and Pathway
Target(s) CD32b Target Info Modulator [531971]
B-lymphocyte antigen CD19 Target Info Modulator
KEGG Pathway Phagosome
Osteoclast differentiation
B cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Staphylococcus aureus infection
Tuberculosis
Measleshsa04151:PI3K-Akt signaling pathway
Hematopoietic cell lineage
Epstein-Barr virus infection
Primary immunodeficiency
NetPath Pathway Leptin Signaling PathwayNetPath_19:IL-7 Signaling Pathway
PANTHER Pathway B cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathwaybcr_5pathway:BCR signaling pathway
Reactome Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellR-HSA-1257604:PIP3 activates AKT signaling
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Constitutive Signaling by Aberrant PI3K in Cancer
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellWP2806:Human Complement System
Signaling by the B Cell Receptor (BCR)
PIP3 activates AKT signaling
B Cell Receptor Signaling Pathway
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
References
Ref 549317Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035125)
Ref 531971CD19 as an attractive target for antibody-based therapy. MAbs. 2012 Sep-Oct;4(5):571-7.

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