Drug Information

Drug General Information
Drug ID
D00NNI
Former ID
DIB007416
Drug Name
ASP-3652
Synonyms
FK-175; Beta 3 adrenoceptor agonists (overactive bladder), Astellas
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Phase 2 [523939]
Company
Astellas Pharma Inc
Canonical SMILES
O=S(=O)(NC(=O)c1c(cc(c2ccc(CCNC[C@@H](c3ccccc3)O)cc2)cc<br />1)SC(C)C)C.Cl
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [548857]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 523939ClinicalTrials.gov (NCT01613586) A Randomized Study Comparing Placebo and ASP3652 in the Treatment of Women With Bladder Pain Syndrome / Interstitial Cystitis (BPS/IC). U.S. National Institutes of Health.
Ref 548857Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029610)

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