Drug Information

Drug General Information
Drug ID
D00LSW
Former ID
DIB013915
Drug Name
VA-111913
Synonyms
VA-111913 TS; VA-913; VT-913; V1a antagonists (dysmenorrhea), Vantia; Vasopressin 1a antagonists (dysmenorrhea), Vantia/Ferring
Drug Type
Small molecular drug
Indication Dysmenorrhea [ICD9: 625.3; ICD10:N94.4-N94.6] Phase 2 [522765]
Company
Ferring Pharmaceuticals Inc
Formula
C23H21ClFN5O2
Canonical SMILES
N1c2c(N(Cc3cnn(c13)C)C(=O)c1cc(c(cc1)CNC(=O)C1CC1)F)ccc<br />(c2)Cl
PubChem Compound ID
45102709
Target and Pathway
Target(s) Vasopressin V1a receptor Target Info Antagonist [550311]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Reactome Vasopressin-like receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 522765ClinicalTrials.gov (NCT00963053) VA111913 Dysmenorrhoea Efficacy and Safety Proof of Concept. U.S. National Institutes of Health.
Ref 550311Clinical pipeline report, company report or official report of Avarx.

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