Drug Information

Drug General Information
Drug ID
D00LMY
Former ID
DIB001231
Drug Name
RO-5212651
Synonyms
GPR119 agonists (type 2 diabetes); RO-5212651; RO-5312776; RO-5328185; RO-5429374; RO-5447603; RO-5447605; RO-5461212; GPR119 agonists (type 2 diabetes), Roche
Indication Non-insulin dependent diabetes [ICD10:E11.9] Investigative [543393]
Company
Roche Holding AG
Canonical SMILES
O=S(=O)(c1nc(c(Oc2c3ccn([C@@H]4[C@@H](CN(CC4)C(=O)OC(C)<br />(C)C)C)c3ncn2)cc1)C)C
Target and Pathway
Target(s) Glucose-dependent insulinotropic receptor Target Info Agonist [543393]
KEGG Pathway cAMP signaling pathway
Insulin secretion
WikiPathways Incretin Synthesis, Secretion, and Inactivation
References
Ref 543393(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126).
Ref 543393(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 126).

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