Drug Information

Drug General Information
Drug ID
D00LHF
Former ID
DIB012710
Drug Name
GS-9219
Synonyms
PMEG prodrug (cancer), Gilead
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1/2 [522061]
Company
Gilead Sciences Inc
Formula
C21H35N8O6P
Canonical SMILES
P(=O)(N[C@H](C(=O)OCC)C)(COCCn1cnc2c1nc(nc2NC1CC1)N)N[C<br />@H](C(=O)OCC)C
PubChem Compound ID
16047979
Target and Pathway
Target(s) DNA polymerase Target Info Inhibitor [529449]
References
Ref 522061ClinicalTrials.gov (NCT00499239) A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or Multiple Myeloma (MM). U.S. National Institutes of Health.
Ref 529449GS-9219--a novel acyclic nucleotide analogue with potent antineoplastic activity in dogs with spontaneous non-Hodgkin's lymphoma. Clin Cancer Res. 2008 May 1;14(9):2824-32.

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