Drug Information

Drug General Information
Drug ID
D00FHI
Former ID
DIB002014
Drug Name
Zabiciprilat
Synonyms
Zabicipril; S-10211; S-9650
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Discontinued in Phase 2 [544560]
Company
Servier
Formula
C21H28N2O5
Canonical SMILES
N1(C(=O)[C@@H](N[C@H](C(=O)O)CCc2ccccc2)C)[C@H](C(=O)O)<br />C2CCC1CC2
PubChem Compound ID
65680
Target and Pathway
Target(s) Angiotensin-converting enzyme Target Info Inhibitor [533956]
KEGG Pathway Renin-angiotensin system
Chagas disease (American trypanosomiasis)
Hypertrophic cardiomyopathy (HCM)
PathWhiz Pathway Angiotensin Metabolism
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways ACE Inhibitor Pathway
Metabolism of Angiotensinogen to Angiotensins
References
Ref 544560Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000139)
Ref 533956Enzyme immunoassays for a new angiotensin-converting enzyme inhibitor, zabicipril, and its active metabolite in human plasma: application to pharmacokinetic studies. Ther Drug Monit. 1993 Oct;15(5):448-54.

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