Drug Information

Drug General Information
Drug ID
D00CQL
Former ID
DIB007215
Drug Name
N-8295
Synonyms
Universal flu vaccine; M2e-ISS; NP-ISS; ISS vaccine (influenza), Dynavax; M2e/NP-ISS; Influenza vaccine (immunostimulatory sequence-based), Dynavax; Influenza vaccine (ND-ISS-based), Dynavax
Drug Type
Vaccine
Indication Influenza virus [ICD10:J11.1] Phase 1 [549878]
Company
Dynavax Technologies Corp
Target and Pathway
Target(s) Toll-like receptor 9 Target Info [547845]
KEGG Pathway Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Malaria
Tuberculosis
Measles
Herpes simplex infection
NetPath Pathway BCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathway
Reactome PI3K Cascade
Trafficking and processing of endosomal TLR
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88 dependent cascade initiated on endosome
Trafficking and processing of endosomal TLR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Regulation of toll-like receptor signaling pathway
References
Ref 549878Clinical pipeline report, company report or official report of Dynavax Technologies Corp.
Ref 547845Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019871)

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