Drug Information

Drug General Information
Drug ID
D00BTW
Former ID
DIB010847
Drug Name
UC-781
Synonyms
Thiocarboxanilide; UC-040; UC-10; UC-82; Oxathiin carboxanilide analogs, Biosyn/CONRAD; UC analogs, Biosyn/CONRAD; Oxathiin carboxanilide analogs, Uniroyal/NCI/Southern Research Institute; UC analogs, Uniroyal/NCI/Southern Research Institute
Drug Type
Small molecular drug
Indication Human immunodeficiency virus infection [ICD9: 279.3; ICD10:B20-B26] Phase 1 [521973], [531646]
Company
Biosyn
Formula
C17H18ClNO2S
Canonical SMILES
c1(C(=S)Nc2cc(c(cc2)Cl)OCC=C(C)C)c(occ1)C
PubChem Compound ID
3000926
Target and Pathway
Target(s) HIV reverse transcriptase Target Info Inhibitor [527689]
References
Ref 521973ClinicalTrials.gov (NCT00441909) Phase I Study of Safety and Persistence of UC-781 Vaginal Microbicide. U.S. National Institutes of Health.
Ref 531646First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One. 2011;6(9):e23243.
Ref 527689The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells. J Virol. 2005 Sep;79(17):11179-86.

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