Details of Metabolite (Meta)

General Information of Metabolite (ID: MT048)
  Meta Name
Inositol trisphosphate (IP3)
  Unify Name
Inositol 1,4,5-trisphosphate
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
1,4,5-Insp3;D-Myo-inositol 1,4,5-trisphosphate;D-MYO-inositol-1,4,5-triphosphATE;Ins(1,4,5)P3;InsP3;IP3;1D-Myo-inositol 1,4,5-trisphosphate;D-Myo-inositol 1,4,5-trisphosphoric acid;D-MYO-inositol-1,4,5-triphosphoric acid;1D-Myo-inositol 1,4,5-trisphosphoric acid;Inositol 1,4,5-trisphosphoric acid;Myo-inositol 1,4,5-trisphosphate;1,4,5-IP3;Inositol 1,4,5-triphosphate;Myoinositol 1,4,5-triphosphate;D-myo-Inositol 1,4,5-triphosphate;IP 3;Inositol 1,4,5-trisphosphate;Inositol triphosphate;Inositol trisphosphate;Triphosphoinositol;myo-Inositol 1,4,5-triphosphate;myo-Inositol triphosphate;myo-Inositol trisphosphate
  Molecule Type
Other metabolites
  Formula
C6H9O15P3
  Inchi Key
MMWCIQZXVOZEGG-HOZKJCLWSA-H
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin. (PubChem). Inositol 1,4,5-trisphosphate (InsP3) is traditionally considered to be the messenger that initiates the increase and spreading of the activating Ca2+ wave. In line with this hypothesis, recent evidence suggests that the penetrating sperm delivers into mammalian eggs a novel isoform of phospholipase C (PLC), which promotes the formation of InsP3. The mechanism by which the interacting sperm triggers the production of NAADP and subsequently that of InsP3 remains obscure. (PMID: 15362223).
  External Links   HMDB ID   HMDB0001498
  VMH ID   mi145p
  KEGG ID   C01245
  Metlin ID   6282

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC3 EM Info Enterocytes . Intestinal diseases [1], [2]

The microbes that produce this metabolite
      Escherichia coli
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Escherichia coli, also known as E. coli, is a gram-negative, facultative anaerobic, rod-shaped, coliform bacteria of the genus Escherichia.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Vitamin B(12) is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation. J Neuroinflammation. 2020 Apr 1;17(1):96. doi: 10.1186/s12974-020-01763-y.

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