Details of Metabolite (Meta) | MIAOME

General Information of Metabolite (ID: MT013)
Meta Name		Taurochenoxycholate
Unify Name		Taurochenoxycholate
Molecule Type		Bile acids (BAs)
Description		Click to Show/Hide the Detailed Description of This Metabolite Tauroursodeoxycholate was not hepatotoxic, whereas taurocholate produced moderate hepatocellular necrosis. Simultaneous infusion of tauroursodeoxycholate to rats receiving taurochenoxycholate or taurodeoxycholate preserved bile flow and ameliorated hepatic injury in a dose-dependent manner.

The epigenetic modification information of this metabolite
Modification Type																				Molecule																				EM Info								Cell/Tissue Type																		Modified sites																						Condition														REF
Histone Deacetylation																				HDAC																				EM Info								.																		.																						.														[1], [2]

The microbes that produce this metabolite
Eubacterium
Detailed Information		MIC Info click to show the detail information of this Microbiota					[3], [1]
Description		Eubacteria is a genus of gram-positive bacteria in the family Eubacteriaceae. These bacteria are characterised by a rigid cell wall. They may either be motile or nonmotile. If motile, they have a flagellum. A typical flagellum consists of a basal body, filament, and hook. The long filament is the organ which helps eubacteria move.
Enterobacter
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1], [2]
Description		Enterobacter is a genus of common gram-negative, facultatively anaerobic, rod-shaped, non-spore-forming bacteria of the family Enterobacteriaceae. It is the type genus of the order Enterobacterales.
Escherichia
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1]
Description		Escherichia is a genus of gram-negative, non-spore-forming, facultatively anaerobic, rod-shaped bacteria from the family Enterobacteriaceae.

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3	Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.

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