Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12405)
  Official Symbol
SMU1
  Official Full Name
SMU1 DNA Replication Regulator And Spliceosomal Factor
  Synonym
SMU1 DNA Replication Regulator And Spliceosomal Factor;FSAP57;SMU-1;BWD;Smu-1 Suppressor Of Mec-8 And Unc-52 Protein Homolog;DNA Replication Regulator And Spliceosomal Factor;FLJ10805;Smu-1 Suppressor Of Mec-8 And Unc-52 Homolog (C. Elegans);SMU1, DNA Replication Regulator And Spliceosomal Factor;Smu-1 Suppressor Of Mec-8 And Unc-52 Homolog;Brain-Enriched WD-Repeat Protein
  Molecule Type
Protein coding
  Position On Chromosome
chr9(Start:33041765 - End:33076705)
  Strand
-
  Uniprot Entry
Q2TAY7 
  ENSG ID
ENSG00000122692 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate SMU1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.