Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12337)
  Official Symbol
PRPF4B
  Official Full Name
Pre-MRNA Processing Factor 4B
  Synonym
Pre-MRNA Processing Factor 4B;KIAA0536;PR4H;Serine/Threonine-Protein Kinase PRP4 Homolog;PRP4 Pre-MRNA-Processing Factor 4 Homolog;PRP4 Kinase;EC 2.7.11.1;PRP4 Pre-MRNA Processing Factor 4 Homolog B;DJ1013A10.1 (PRP4 Protein Kinase Homolog);Protein-Serine/Threonine Kinase;DJ1013A10.1
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:4021267 - End:4064983)
  Strand
+
  Uniprot Entry
Q13523 
  ENSG ID
ENSG00000112739 
    Disease Relevance (Click to Show/Hide)
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PRPF4B CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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