Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12329)
  Official Symbol
PPP2CA
  Official Full Name
Protein Phosphatase 2 Catalytic Subunit Alpha
  Synonym
Protein Phosphatase 2 Catalytic Subunit Alpha;PP2Calpha;Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform;Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme;Replication Protein C;EC 3.1.3.16;Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform;Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform;NEDLBA;PP2Ac;PP2CA
  Molecule Type
Protein coding
  Position On Chromosome
chr5(Start:134194332 - End:134226073)
  Strand
-
  Uniprot Entry
P67775 
  ENSG ID
ENSG00000113575 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         6B01: Panic disorder Panic Disorder [Panic disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
            Detailed Information Disease Link click to show the detail information of this Disease
         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate PPP2CA CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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