Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12286)
  Official Symbol
OR4X1
  Official Full Name
Olfactory Receptor Family 4 Subfamily X Member 1
  Synonym
Olfactory Receptor OR11-104;Olfactory Receptor Family 4 Subfamily X Member 1;Olfactory Receptor 4X1;Olfactory Receptor, Family 4, Subfamily X, Member 1 (Gene/Pseudogene);Olfactory Receptor Family 4 Subfamily X Member 1 (Gene/Pseudogene);Olfactory Receptor, Family 4, Subfamily X, Member 1;OR11-104
  Molecule Type
Protein coding
  Position On Chromosome
chr11(Start:48263861 - End:48264778)
  Strand
+
  Uniprot Entry
Q8NH49 
  ENSG ID
ENSG00000176567 
    Disease Relevance (Click to Show/Hide)
         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
            Detailed Information Disease Link click to show the detail information of this Disease
         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate OR4X1 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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