Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12273)
Official Symbol		NUDT18
Official Full Name		Nudix Hydrolase 18
Synonym		Nudix Hydrolase 18;Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 18;MTH3;Nucleoside Diphosphate-Linked Moiety X Motif 18;7,8-Dihydro-8-Oxoguanine Phosphatase;8-Oxo-DGDP Phosphatase NUDT18;MutT Homolog 3;Nudix Motif 18;FLJ22494;EC 3.6.1.58;EC 3.6.1
Molecule Type		Protein coding
Position On Chromosome		chr8(Start:22106872 - End:22110355)
Strand		-
Uniprot Entry		Q6ZVK8
ENSG ID		ENSG00000275074
Disease Relevance (Click to Show/Hide)
8A01: Choreiform disorders		Huntington's disease (HD) [Choreiform disorders]
Detailed Information		Disease Link click to show the detail information of this Disease
8A20: Alzheimer disease		Alzheimer's disease [Alzheimer disease]
Detailed Information		Disease Link click to show the detail information of this Disease
CB03: Idiopathic interstitial pneumonitis		Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
Detailed Information		Disease Link click to show the detail information of this Disease
LD2C: Overgrowth syndromes		Sotos syndrome(SS) [Overgrowth syndromes]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate NUDT18 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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