Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12267)
Official Symbol		NR0B1
Official Full Name		Nuclear Receptor Subfamily 0 Group B Member 1
Synonym		Nuclear Receptor Subfamily 0 Group B Member 1;DAX1;AHCH;AHC;DSS-AHC Critical Region On The X Chromosome Protein 1;Nuclear Receptor DAX-1;DSS;Truncated Nuclear Receptor Subfamily 0 Group B Member 1;Nuclear Receptor Subfamily 0, Group B, Member 1;DAX-1;NROB1;SRXY2;AHX;GTD;HHG
Molecule Type		Protein coding
Position On Chromosome		chrX(Start:30304206 - End:30309390)
Strand		-
Uniprot Entry		P51843
ENSG ID		ENSG00000169297
Disease Relevance (Click to Show/Hide)
ZERO(Not Found): Sex chromosome anomalies		X-chromosome inactivation (XCI) [Sex chromosome anomalies]
Detailed Information		Disease Link click to show the detail information of this Disease

Metabolite(s) with this epigenetic modification
Metabolite Name: Valerate
Detailed Information	Meta Info click to show the detail information of this Metabolite	[1], [2]
Description	Valerate has been shown to hypermethylate NR0B1 CpG site in breast cancer cells.

References
1	Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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