Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12253)
  Official Symbol
NDUFAF3
  Official Full Name
NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 3
  Synonym
NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 3;C3orf60;E3-3;NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, Assembly Factor 3;2P1;NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Assembly Factor 3;MGC10527;Chromosome 3 Open Reading Frame 60;Nuclear Protein E3-3;MC1DN18;NADH Dehydrogenase (Ubiquinone) Complex I, Assembly Factor 3
  Molecule Type
Protein coding
  Position On Chromosome
chr3(Start:49020452 - End:49023495)
  Strand
+
  Uniprot Entry
Q9BU61 
  ENSG ID
ENSG00000178057 
    Disease Relevance (Click to Show/Hide)
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate NDUFAF3 CpG site in breast cancer cells.

References
1 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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